Nature manuscript 2012-10-12908C High-resolution cryo-EM structure of Trypanosoma brucei 80S: A unique eukaryotic ribosome
نویسندگان
چکیده
1HHMI, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA 2Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA 3Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY, USA 4Architecture et Réactivité de l’ARN, Université de Strasbourg, Institut de Biologie Moléculaire et Cellulaire (CNRS), Strasbourg, France
منابع مشابه
Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution.
Protein biosynthesis, the translation of the genetic code into polypeptides, occurs on ribonucleoprotein particles called ribosomes. Although X-ray structures of bacterial ribosomes are available, high-resolution structures of eukaryotic 80S ribosomes are lacking. Using cryoelectron microscopy and single-particle reconstruction, we have determined the structure of a translating plant (Triticum ...
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Ribosomes are the protein synthesizing machines of the cell. Recent advances in cryo-EM have led to the determination of structures from a variety of species, including bacterial 70S and eukaryotic 80S ribosomes as well as mitoribosomes from eukaryotic mitochondria, however, to date high resolution structures of plastid 70S ribosomes have been lacking. Here we present a cryo-EM structure of the...
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